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Formation of High-axial-ratio-microstructures from Natural and Synthetic Sphingolipids by Alex S Goldstein; Anatoly N Lukyanov; Paul A Carlson; Paul Yager; Michael H Gelb is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Formation of High-axial-ratio-microstructures from Natural and Synthetic Sphingolipids about?

Amphiphiles that form high-axial-ratio-microstructures (HARMs) are being considered as novel materials for controlled release of drugs and other biologically functional molecules. HARMs consisting of tubules, ribbons, solid rods and helices are formed from sphingolipids by addition of water to a solution of amphiphile in DMF. Single molecular species of galactocerebroside (GalCer) containing long unsaturated fatty acid chains or natural GalCer containing mixed-length, non-hydroxy fatty acids (NFA-GalCer) or alpha-hydroxy fatty acids (HFA-GalCer) form cylindrical structures. In contrast, single molecular species of GalCer containing long saturated fatty acids form ribbons and helices. GalCer HARMs are typically under 100 nm in diameter and have lengths of several microns. The importance of the amide of GalCer for HARM formation was evaluated using psychosine, which forms solid fibers, whereas sphingosine and an analog of GalCer in which the amide is reduced to a secondary amine form amorphous aggregates. Single molecular species of ceramide containing long unsaturated fatty acid chains form cylindrical structures, whereas those with long saturated fatty acids form ribbons and helice

Who reads Formation of High-axial-ratio-microstructures from Natural and Synthetic Sphingolipids?

Author

Alex S Goldstein; Anatoly N Lukyanov; Paul A Carlson; Paul Yager; Michael H Gelb

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-3084)

Published

1997

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)