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Site as a Prognostic Factor in Patients With Stage III/IV Squamous Cell Carcinoma of the Head and Neck Following Definitive Chemoradiation by K. Carter; K. Settle; R. Taylor; J. Wolf; Y. Kwok; K. Cullen; R. Ord; A. Zimrin; S. Strome; M. Suntharalingam is a Medicine article available to read on EtoBox.

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There were 17 females and 50 males, with a median age of 48 (range 18-69). According to the stage classification, the disease was Stage III in 52 and Stage IVa in 15. IMRT method was carried out using an inverse planning system (Pinnacle 3 version 7.6 c, Philips). The prescription dose was 66 Gy/30Fx for the lesion with complete response (CR) or good partial response (PR) after neoadjuvant chemotherapy, 70.4 Gy/32Fx for the other primary lesion, 60-66 Gy/30Fx to positive neck lymph nodes, 60 Gy/30Fx to the high risk clinical target volume and 54 Gy/30Fx to the low risk clinical target volume. The chemotherapy protocol is based on 2 courses of neoadjuvant chemotherapy (5 Fluorouracyl 750 mg/m 2 , leucovorin 60 mg/m 2 and cisplatin 30 mg/m 2 for 3 days, repeated at 22 nd day) and 3 courses of adjuvant chemotherapy with the same scheme. The adjuvant regimen will be given within 2 weeks after radiotherapy. Kaplan-Meier method was used to calculate the overall survival rate (OS), disease-free survival rates (DFS), and local-regional control rates from the beginning date of radiotherapy. Results: The median follow-up time was 18 months (range 9 to 23 months). Histopathological diagnosis

Who reads Site as a Prognostic Factor in Patients With Stage III/IV Squamous Cell Carcinoma of the Head and Neck Following Definitive Chemoradiation?

Author

K. Carter; K. Settle; R. Taylor; J. Wolf; Y. Kwok; K. Cullen; R. Ord; A. Zimrin; S. Strome; M. Suntharalingam

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2007

Language

EN

Field

Medicine (Health Sciences)