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The document discusses therapeutic drug monitoring (TDM) focusing on dosing adjustments in special populations, particularly those with renal or hepatic diseases, heart failure, and obesity. It outlines methods for estimating renal function, including creatinine clearance and glomerular filtration rate, and introduces the Child-Pugh score for assessing hepatic function. The document emphasizes the importance of TDM in ensuring safe and effective therapy by adjusting dosages based on individual patient needs

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zx3621zx
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