Can I read Molecular Subclasses of Preeclampsia Characterized by a Longitudinal Maternal Proteomics Study: Distinct Biomarkers, Disease Pathways and Options for Prevention on EtoBox?

Molecular Subclasses of Preeclampsia Characterized by a Longitudinal Maternal Proteomics Study: Distinct Biomarkers, Disease Pathways and Options for Prevention by Nándor Gábor Than; Roberto Romero; Dániel Györffy; Máté Posta; Gaurav Bhatti; Bogdan Done; Piya Chaemsaithong; Eunjung Jung; Manaphat Suksai; Francesca Gotsch; Dahiana M. Gallo; Mariachiara Bosco; Bomi Kim; Yeon Mee Kim; Tinnakorn Chaiworapongsa; Simona W. Rossi; András Szilágyi; Offer Erez; Adi L. Tarca; Zoltán Papp is a Medicine article available to read on EtoBox.

What is Molecular Subclasses of Preeclampsia Characterized by a Longitudinal Maternal Proteomics Study: Distinct Biomarkers, Disease Pathways and Options for Prevention about?

## Abstract ## Objectives The heterogeneous nature of preeclampsia is a major obstacle to early screening and prevention, and a molecular taxonomy of disease is needed. We have previously identified four subclasses of preeclampsia based on first-trimester plasma proteomic profiles. Herein, we expanded this approach by using a more comprehensive panel of proteins profiled in longitudinal samples. ## Methods Proteomic data collected longitudinally from plasma samples of women who developed preeclampsia (n=109) and of controls (n=90) were available from our previous report on 1,125 proteins. Consensus clustering was performed to identify subgroups of patients with preeclampsia based on data from five gestational-age intervals by using select interval-specific features. Demographic, clinical, and proteomic differences among clusters were determined. Differentially abundant proteins were used to identify cluster-specific perturbed KEGG pathways. ## Results Four molecular clusters with different clinical phenotypes were discovered by longitudinal proteomic profiling. Cluster 1 involves metabolic and prothrombotic changes with high rates of early-onset preeclampsia and small-for-gestation

Who reads Molecular Subclasses of Preeclampsia Characterized by a Longitudinal Maternal Proteomics Study: Distinct Biomarkers, Disease Pathways and Options for Prevention?

Author

Nándor Gábor Than; Roberto Romero; Dániel Györffy; Máté Posta; Gaurav Bhatti; Bogdan Done; Piya Chaemsaithong; Eunjung Jung; Manaphat Suksai; Francesca Gotsch; Dahiana M. Gallo; Mariachiara Bosco; Bomi Kim; Yeon Mee Kim; Tinnakorn Chaiworapongsa; Simona W. Rossi; András Szilágyi; Offer Erez; Adi L. Tarca; Zoltán Papp

Publisher

Walter de Gruyter GmbH

Published

2022

Language

EN

Field

Medicine (Health Sciences)