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Anticonvulsant effect of acute curcumin nanoparticle on pentylenetetrazole-induced seizures in mice: non-involvement of JNK restoration by Leila Moezi; Nanobiology and Nanomedicine Research Centre, Shiraz University of Medical sciences, Shiraz, Iran; Nahid Ashjazadeh; Shirin Rezapanah; Fatema Pirsalami; Zahra Esmaeili; Roksana SoukhakLari; Maryam Moosavi; Clinical Neurology Research Center and Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran; Clinical Neurology Research Center and Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmacology, Medical School, Shiraz University of Medical sciences, Shiraz, Iran; Nanobiology and Nanomedicine Research Centre, Shiraz University of Medical sciences, Shiraz, Iran; Shiraz Neuroscience Research Centre, Shiraz University of Medical sciences, Shiraz, Iran; Nanobiology and Nanomedicine Research Centre, Shiraz University of Medical sciences, Shiraz, Iran is a Neuroscience article available to read on EtoBox.

What is Anticonvulsant effect of acute curcumin nanoparticle on pentylenetetrazole-induced seizures in mice: non-involvement of JNK restoration about?

Introduction: Although several animal studies have indicated the antiepileptic effect for curcumin, there are reports stating the null antiepileptic effect of this substance. This inconsistency might be due to the low bioavailability of curcumin. Therefore, the current study aimed to assess the effect of oral bovine serum albumin (BSA)-based nanocurcumin on seizure caused by pentylenetetrazol (PTZ) in mice. Furthermore, due to the suggested involvement of JNK signaling in seizure pathology, the hippocampal pattern of JNK phosphorylation (activation) was evaluated. Methods: BSA based nanocurcumin was administered at doses of 50 and 100mg/kg oral gavage to male NMRI mice, one hour before PTZ administration. Intravenous PTZ paradigm was used to determine the threshold dose of PTZ to induce clonic seizures, while the intraperitoneal PTZ paradigm was applied to evaluate the latency for appearance of generalized clonus. Upon completion of intraperitoneal PTZ paradigm experiments, the hippocampi were removed and Western blot analysis was performed to determine the phosphorylated and total forms of JNK. Results: The results indicated that BSA-based nanocurcumin at the doses of 50 and 100mg

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Author

Leila Moezi; Nanobiology and Nanomedicine Research Centre, Shiraz University of Medical sciences, Shiraz, Iran; Nahid Ashjazadeh; Shirin Rezapanah; Fatema Pirsalami; Zahra Esmaeili; Roksana SoukhakLari; Maryam Moosavi; Clinical Neurology Research Center and Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran; Clinical Neurology Research Center and Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmacology, Medical School, Shiraz University of Medical sciences, Shiraz, Iran; Nanobiology and Nanomedicine Research Centre, Shiraz University of Medical sciences, Shiraz, Iran; Shiraz Neuroscience Research Centre, Shiraz University of Medical sciences, Shiraz, Iran; Nanobiology and Nanomedicine Research Centre, Shiraz University of Medical sciences, Shiraz, Iran

Publisher

CMV Verlag

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)