Can I read White-matter free-water diffusion MRI in schizophrenia: a systematic review and meta-analysis on EtoBox?

White-matter free-water diffusion MRI in schizophrenia: a systematic review and meta-analysis by Inês Carreira Figueiredo; Faith Borgan; Ofer Pasternak; Federico E. Turkheimer; Oliver D. Howes is a Neuroscience article available to read on EtoBox.

What is White-matter free-water diffusion MRI in schizophrenia: a systematic review and meta-analysis about?

White-matter abnormalities, including increases in extracellular free-water, are implicated in the pathophysiology of schizophrenia. Recent advances in diffusion magnetic resonance imaging (MRI) enable free-water levels to be indexed. However, the brain levels in patients with schizophrenia have not yet been systematically investigated. We aimed to meta-analyse white-matter free-water levels in patients with schizophrenia compared to healthy volunteers. We performed a literature search in EMBASE, MEDLINE, and PsycINFO databases. Diffusion MRI studies reporting free-water in patients with schizophrenia compared to healthy controls were included. We investigated the effect of demographic variables, illness duration, chlorpromazine equivalents of antipsychotic medication, type of scanner, and clinical symptoms severity on free-water measures. Ten studies, including five of first episode of psychosis have investigated free-water levels in schizophrenia, with significantly higher levels reported in whole-brain and specific brain regions (including corona radiata, internal capsule, superior and inferior longitudinal fasciculus, cingulum bundle, and corpus callosum). Six studies, includin

Who reads White-matter free-water diffusion MRI in schizophrenia: a systematic review and meta-analysis?

Author

Inês Carreira Figueiredo; Faith Borgan; Ofer Pasternak; Federico E. Turkheimer; Oliver D. Howes

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Neuroscience (Life Sciences)