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Benefits and harms of breast cancer mammography screening for women at average risk of breast cancer: A systematic review for the European Commission Initiative on Breast Cancer by Carlos Canelo-Aybar; Diogenes S Ferreira; Mónica Ballesteros; Margarita Posso; Nadia Montero; Ivan Solà; Zuleika Saz-Parkinson; Donata Lerda; Paolo G Rossi; Stephen W Duffy; Markus Follmann; Axel Gräwingholt; Pablo Alonso-Coello is a Medicine article available to read on EtoBox.

What is Benefits and harms of breast cancer mammography screening for women at average risk of breast cancer: A systematic review for the European Commission Initiative on Breast Cancer about?

Objectives: Mammography screening is generally accepted in women aged 50-69, but the balance between benefits and harms remains controversial in other age groups. This study systematically reviews these effects to inform the European Breast Cancer Guidelines. Methods: We searched PubMed, EMBASE and Cochrane Library for randomised clinical trials (RCTs) or systematic reviews of observational studies in the absence of RCTs comparing invitation to mammography screening to no invitation in women at average breast cancer (BC) risk. We extracted data for mortality, BC stage, mastectomy rate, chemotherapy provision, overdiagnosis and false-positive-related adverse effects. We performed a pooled analysis of relative risks, applying an inversevariance random-effects model for three age groups (<50, 50-69 and 70-74). GRADE (Grading of Recommendations Assessment, Development and Evaluation) was used to assess the certainty of evidence. Results: We identified 10 RCTs including 616,641 women aged 38-75. Mammography reduced BC mortality in women aged 50-69 (relative risk (RR) 0.77, 95%CI (confidence interval) 0.66-0.90, high certainty) and 70-74 (RR 0.77, 95%CI 0.54-1.09, high certainty), with s

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Author

Carlos Canelo-Aybar; Diogenes S Ferreira; Mónica Ballesteros; Margarita Posso; Nadia Montero; Ivan Solà; Zuleika Saz-Parkinson; Donata Lerda; Paolo G Rossi; Stephen W Duffy; Markus Follmann; Axel Gräwingholt; Pablo Alonso-Coello

Publisher

SAGE Publications

Published

2021

Language

EN

Field

Medicine (Health Sciences)