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A Clinical Study on the Correlation Between Demodex Infestation and Ocular Surface Changes in Patients with Meibomian Gland Dysfunction by Yan Chen; Shuling Pan is a Medicine article available to read on EtoBox.

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## Purpose: To observe the effect of demodex infection on the ocular surface changes of patients with meibomian gland dysfunction (MGD) and analyze the correlation between the number of demodex and the changes of the ocular surface. ## Methods: Hundred patients with MGD aged 18–70 years who visited the dry eye center of Shanghai Aier Eye Hospital were recruited. All patients were examined with __in vivo__ confocal microscopy to quantify the demodex and divided them into two groups (demodex negative group and demodex positive group) according to the number of demodex mites. The subjects underwent questionnaires of ocular surface disease index (OSDI) and a series of examinations. Parameters including the OSDI score, fluorescein tear film break-up time (FBUT), meibum quality, meibum gland expressibility, meibomian gland dropout (MG dropout), and ocular redness were recorded and compared between the two groups. The correlation between the number of demodex and the ocular surface changes was further analyzed. ## Results: Among 100 patients, 51 were positive for __demodex__. The __demodex-__positive group showed significantly increased scores of OSDI (24.41 ± 3.43 __vs__ 20.98 ± 2.31, __

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Author

Yan Chen; Shuling Pan

Published

2021

Language

EN

Field

Medicine (Health Sciences)