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Brain Metastases in Children with Solid Tumors by Eric Bouffet; Nasser Doumi; Philippe Thiesse; Carmine Mottolese; Anne Jouvet; Michel Lacroze; Christian Carrie; Didier Frappaz; Maud Brunat-Mentigny is a Medicine article available to read on EtoBox.

What is Brain Metastases in Children with Solid Tumors about?

## Background: Brain metastases are uncommon among children with solid tumors. however, improvements in survival have increased the period of time during which children are at risk for developing these metastases. the authors reviewed brain metastases in children with solid tumors treated at the centre léon bérard during the 9 years between 1987 and 1995. ## Methods: Among 486 patients with solid tumors, 162 eventually developed distant metastases in their disease process, including 12 brain metastases detected by imaging. the tumor type, clinical setting, imaging characteristics, treatment modalities, and outcome were assessed for each patient. ## Results: The most common tumors causing brain metastases were ewing's sarcoma (in three patients), neuroblastoma (in three patients), and osteogenic sarcoma (in three patients). at the time of initial diagnosis, 9 of the 12 patients had metastatic disease. all but one patient initially received intensive multiagent chemotherapy, including high dose chemotherapy with bone marrow rescue in six patients. the median time from initial diagnosis to the detection of brain metastases was 15 months. these metastases were clinically detectable in

Who reads Brain Metastases in Children with Solid Tumors?

Author

Eric Bouffet; Nasser Doumi; Philippe Thiesse; Carmine Mottolese; Anne Jouvet; Michel Lacroze; Christian Carrie; Didier Frappaz; Maud Brunat-Mentigny

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1997

Language

EN

Field

Medicine (Health Sciences)