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Use of Calcium-channel Blockers in Pediatric Renal Transplant Recipients by Douglas M. Silverstein; JoAnn Palmer; H. Jorge Baluarte; Caroline Brass; Susan B. Conley; Martin S. Polinsky is a Medicine article available to read on EtoBox.

What is Use of Calcium-channel Blockers in Pediatric Renal Transplant Recipients about?

Abstract: Hypertension (HTN) is a significant problem in pediatric renal transplant (TP) recipients, predisposing the individuals to the development of cardiovascular disease and graft dysfunction. Calcium channel blockers (CCB) are considered excellent agents to treat post‐TP HTN. We compared the efficacy and adverse effects of the two most commonly prescribed CCBs in our pediatric renal TP population: nifedipine (Procardia^R^, or P) and amlodipine (Norvasc^R^, or N)__.__ All patients (n = 24) had been started on a CCB for systolic (SBP) and/or diastolic BP (DBP) > 95%. There were no other changes in adjunctive antihypertensive medications or doses during the cross‐over period. Post‐TP, pretreatment (pretx) SBP was 137.6 ± 10.9 mmHg. The post‐treatment SBP were (in mmHg): 128.5 ± 11.9 (all patients, n = 24) (p = 0.009 vs. pretx); 126.4 ± 10.0 (P alone, n = 15) (p = 0.007 vs. pretx); 132.8 ± 14.4 (P + other antihypertensive(s), n = 9) (p = 0.331, NS vs. pretx). The post‐TP, pretreatment DBP was 88.2 ± 11.1 mmHg. The post‐treatment DBP were (in mmHg): 78.5 ± 6.9 (all patients, n = 24) (p = 0.03 vs. pretx); 77.2 ± 7.4 (P alone, n = 15) (p = 0.008 vs. pretx); 80.7 ± 6.1(P + other anti

Who reads Use of Calcium-channel Blockers in Pediatric Renal Transplant Recipients?

Author

Douglas M. Silverstein; JoAnn Palmer; H. Jorge Baluarte; Caroline Brass; Susan B. Conley; Martin S. Polinsky

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 1397-3142)

Published

1999

Language

EN

Field

Medicine (Health Sciences)