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Targeting Dendritic Cells for Priming Cellular Immune Responses by Péter Gogolák; Bence Réthi; György Hajas; Éva Rajnavölgyi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Targeting Dendritic Cells for Priming Cellular Immune Responses about?

## Abstract The cardinal role of dendritic cells (DC) in priming adaptive immunity and in orchestrating immune responses against all classes of pathogens and also against tumors is well established. Their unique potential both to maintain self‐tolerance and to initiate protective immune responses against foreign and/or dangerous structures is based on the functional diversity and flexibility of these cells. Tissue DC lining antigenic portals such as mucosal surfaces and the skin are specialized to take up a wide array of compounds including proteins, lipids, carbohydrates, glycoproteins, glycolipids and oligonucleotides, particles carrying such structures and apoptotic or necrotic cells. This process is facilitated by specialized receptors with high endocytic capacity, which provides potential targets for delivering designed molecules. The best route for targeting B‐ and/or T cell epitopes, however, is still the subject of intense investigation. Immature DC, which reside in various tissues, can be activated by pathogens, stress and inflammation or modified metabolic products, which induce mobilization of cells to draining lymph nodes where they act as highly potent professional ant

Who reads Targeting Dendritic Cells for Priming Cellular Immune Responses?

Author

Péter Gogolák; Bence Réthi; György Hajas; Éva Rajnavölgyi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0952-3499)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)