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A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve by V Praveen Chakravarthi; Subhra Ghosh; Katherine F Roby; Michael W Wolfe; M A Karim Rumi is a Medicine article available to read on EtoBox.

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## Abstract Over the entire reproductive lifespan in mammals, a fixed number of primordial follicles serve as the source of mature oocytes. Uncontrolled and excessive activation of primordial follicles can lead to depletion of the ovarian reserve. We observed that disruption of estrogen receptor β (ESR2) signaling results in increased activation of primordial follicles in Esr2-null (Esr2–/–) rats. However, follicle assembly was unaffected, and the total number of follicles remained comparable between neonatal wild-type and Esr2–/– ovaries. While the activated follicle counts were increased in Esr2–/– ovary, the number of primordial follicles were markedly decreased. Excessive recruitment of primordial follicles led to premature ovarian senescence in Esr2–/– rats and was associated with reduced levels of serum AMH and estradiol. Disruption of ESR2 signaling through administration of a selective antagonist (PHTPP) increased the number of activated follicles in wildtype rats, whereas a selective agonist (DPN) decreased follicle activation. In contrast, primordial follicle activation was not increased in the absence of ESR1, indicating that the regulation of primordial follicle activat

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Author

V Praveen Chakravarthi; Subhra Ghosh; Katherine F Roby; Michael W Wolfe; M A Karim Rumi

Publisher

Endocrine Society; The Endocrine Society; Oxford University Press; Oxford University Press (OUP) (ISSN 0013-7227)

Published

2020

Language

EN

Field

Medicine (Health Sciences)