Opening book details…
Can I read A Physico‐chemical Properties Based Model for Estimating Evaporation and Absorption Rates of Perfumes from Skin^¶^ on EtoBox?
A Physico‐chemical Properties Based Model for Estimating Evaporation and Absorption Rates of Perfumes from Skin^¶^ by G.B. Kasting; P. Saiyasombati is a Medicine article available to read on EtoBox.
What is A Physico‐chemical Properties Based Model for Estimating Evaporation and Absorption Rates of Perfumes from Skin^¶^ about?
Synopsis Because of their potential for inducing allergic contact dermatitis (ACD) if used improperly, perfumes are carefully assessed for dermal safety prior to incorporation into cosmetic products. Exposure assessment for these materials often involves the conservative assumption of 100% absorption of each component. This report describes an improved method to estimate the absorption and evaporation of perfume ingredients from skin, based on their physico‐chemical properties. The effect of environmental variables such as temperature and wind velocity can be accounted for in a logical way. This was accomplished using a first‐order kinetic approach expected to be applicable for small doses applied to skin. Skin penetration rate was calculated as a fraction of the maximum flux estimated from the compound’s lipid solubility, __S__~__lip__~ (represented by the product of octanol/water partition coefficient, __K__~__oct__t~, and water solubility, __S__~__w__~), and molecular weight, __MW__. Evaporation rates were estimated from a modified Henry’s Law approach with a stagnant boundary layer whose thickness is a function of surface airflow, __v__. At a given value of __v__, evaporation r
Who reads A Physico‐chemical Properties Based Model for Estimating Evaporation and Absorption Rates of Perfumes from Skin^¶^?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- G.B. Kasting; P. Saiyasombati
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Springer Science and Business Media LLC; Wiley (ISSN 0142-5463)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)