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Biomimetic Rebuilding of Multifunctional Red Blood Cells: Modular Design Using Functional Components by Guo, Jimin; Agola, Jacob Ongudi; Serda, Rita; Franco, Stefan; Lei, Qi; Wang, Lu; Minster, Joshua; Croissant, Jonas G.; Butler, Kimberly S.; Zhu, Wei; Brinker, C. Jeffrey is a Engineering article available to read on EtoBox.
What is Biomimetic Rebuilding of Multifunctional Red Blood Cells: Modular Design Using Functional Components about?
The design and synthesis of artificial materials that mimic the structures, mechanical properties, and ultimately functionalities of biological cells remains a current holy grail of materials science. Here, based on a silica cell bioreplication approach, we report the design and construction of synthetic rebuilt red blood cells (RRBCs) that fully mimic the broad properties of native RBCs: size, biconcave shape, deformability, oxygen-carrying capacity, and long circulation time. Four successive nanoscale processing steps (RBC bioreplication, layer-by-layer polymer deposition, and precision silica etching, followed by RBC ghost membrane vesicle fusion) are employed for RRBC construction. A panel of physicochemical analyses including zeta-potential measurement, fluorescence microscopy, and antibody-mediated agglutination assay proved the recapitulation of RBC shape, size, and membrane structure. Flow-based deformation studies carried out in a microfluidic blood capillary model confirmed the ability of RRBCs to deform and pass through small slits and reconstitute themselves in a manner comparable to native RBCs. Circulation studies of RRBCs conducted in a chick embryo and in a mouse mo
Who reads Biomimetic Rebuilding of Multifunctional Red Blood Cells: Modular Design Using Functional Components?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Guo, Jimin; Agola, Jacob Ongudi; Serda, Rita; Franco, Stefan; Lei, Qi; Wang, Lu; Minster, Joshua; Croissant, Jonas G.; Butler, Kimberly S.; Zhu, Wei; Brinker, C. Jeffrey
- Publisher
- American Chemical Society; American Chemical Society (ACS) (ISSN 1936-0851)
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)