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The association between activated protein C ratio and Factor V Leiden are gender-dependent by Rasmus Søgaard Hansen; Mads Nybo is a Medicine article available to read on EtoBox.

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## Abstract ## Background The most common cause of activated protein C (aPC) resistance is a missense substitution (__Arg506Gln__), known as Factor V Leiden (__FVL__). Due to its low cost, many laboratories use the aPC ratio as a primary test with a unisex cut-off. However, the association between the aPC ratio and __FVL__ including any relation to gender has been sparsely investigated. ## Methods Results of the aPC ratio and __FVL__ analyses from 1081 patients referred to the Thrombophilia Clinic at Odense University Hospital were compared. ## Results In 153 __FVL__ positive patients, the mean aPC ratio was 2.1 ± 0.3, which differed from 2.7 ± 0.4 in __FVL__ negative individuals (p < 0.01). The receiver operating characteristics (ROC), with area under the curve (AUC) of 0.93, indicated the optimal aPC cut-off at 2.3–2.4, with sensitivity 89%–94%, specificity 71%–84%, positive predictive value 35%–48% and negative predictive value 98%–99%. In __FVL__ positive females, the mean aPC ratio was 2.0 ± 0.3, which differed from males (2.1 ± 0.3, p < 0.05). In __FVL__ negative females, the mean aPC ratio was 2.6 ± 0.4, also different from males (2.8 ± 0.5, p < 0.01). Of note, 35% of __FVL_

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Author

Rasmus Søgaard Hansen; Mads Nybo

Publisher

Walter de Gruyter GmbH

Published

2019

Language

EN

Field

Medicine (Health Sciences)