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Simple Fabrication and Enhanced Bioactivity of Bioglass‐Poly(lactic‐co‐glycolic acid) Composite Scaffolds with Matrix Microporosity by Dhanalakshmi Jeyachandran; Li Li; Rayan Fairag; Lisbet Haglund; Marta Cerruti is a Materials Science article available to read on EtoBox.

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## Abstract Scaffold porosity plays an important role in bone tissue engineering as macropores promote cell migration and micropores promote protein adsorption and cell adhesion. Currently, most methods use complex, multi‐step processes to create dual‐scale porosity in composite scaffolds, and no studies evaluate the effect of microporosity on the bioactivity of composite scaffolds with dual porosity. To fill this gap, a simple solvent casting and porogen leaching technique using paraffin microspheres as a porogen and CitriSolv as the leaching solvent to prepare macroporous Bioglass‐poly(lactic‐co‐glycolic acid) (Bg‐PLGA) scaffolds with intrinsic micropores (1–10 μm) in the PLGA matrix is proposed, and the effect of microporosity on the bioactivity of the scaffolds is analyzed. PLGA matrix microporosity induces larger apatite deposition upon immersion in simulated body fluid, as well as enhanced protein adsorption upon contact with serum, compared to non‐microporous scaffolds. Also, mesenchymal cells cultured on the microporous scaffolds show extensive matrix deposition. These results highlight this method as a simple and effective technique to produce dual‐porosity scaffolds that

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Author

Dhanalakshmi Jeyachandran; Li Li; Rayan Fairag; Lisbet Haglund; Marta Cerruti

Publisher

Wiley

Published

2022

Language

EN

Field

Materials Science (Physical Sciences)