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Fetal microchimerisms in the mother: Immunologic implications by Atsushi Tanaka; Keith Lindor; Aftab Ansari; M. Eric Gershwin is a Medicine article available to read on EtoBox.

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The previously held concept that the fetus is completely separated from the mother, especially by trophoblasts that line the outer layer of the placenta, has recently been questioned. It has recently been shown that fetal cells are detectable not only in the peripheral blood, but also in maternal skin and liver. Although the migration of fetal cells into the maternal circulation has been given a great deal of attention because of its implication in the prenatal diagnosis of genetic diseases, the potential role of such placental transfer of fetal cells in the pathogenesis of autoimmune diseases has only recently been considered. In patients with scleroderma, fetal cell-derived DNA was detected more frequently in the peripheral blood of patients than controls. This finding of a limited number of fetal cells in maternal tissues leading to microchimerism has been proposed to have a role in the induction of scleroderma. Although evidence for microchimerism has also been confirmed in a high frequency of liver tissues from patients with primary biliary cirrhosis (PBC), a similar high frequency was noted in control patients, which suggests that microchimerism by itself is unlikely to fully

Who reads Fetal microchimerisms in the mother: Immunologic implications?

Author

Atsushi Tanaka; Keith Lindor; Aftab Ansari; M. Eric Gershwin

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2000

Language

EN

Field

Medicine (Health Sciences)