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A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function by Yazdani, Akram; Yazdani, Azam; Giráldez, Raúl Méndez; Aguilar, David; Sartore, Luca is a scholarly article available to read on EtoBox.

What is A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function about?

Heart failure is a major cause for premature death. Given heterogeneity of the heart failure syndrome, identifying genetic determinants of cardiac function and structure may provide greater insights into heart failure. Despite progress in understanding the genetic basis of heart failure through genome wide association studies, heritability of heart failure is not well understood. Gaining further insights into mechanisms that contribute to heart failure requires systematic approaches that go beyond single trait analysis. We integrated Bayesian multi-trait approach and Bayesian networks for the analysis of 10 correlated traits of cardiac structure and function measured for 3387 individuals with whole exome sequence data. While using single-trait based approaches did not find any significant genetic variant, applying the integrative Bayesian multi-trait approach, we identified 3 novel variants located in genes, RGS3, CHD3, and MRPL38 with significant impact on the cardiac traits such as left ventricular volume index, parasternal long axis interventricular septum thickness, and mean left ventricular wall thickness. Among these, the rare variant NC_000009.11:g.116346115C>A (rs144636307)

Author

Yazdani, Akram; Yazdani, Azam; Giráldez, Raúl Méndez; Aguilar, David; Sartore, Luca

Published

2018

Language

EN