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Severe Asthmatic Responses: The Impact of TSLP by Efthymia Theofani; Aikaterini Tsitsopoulou; Ioannis Morianos; Maria Semitekolou is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Severe Asthmatic Responses: The Impact of TSLP about?

Asthma is a chronic inflammatory disease that affects the lower respiratory system and includes several categories of patients with varying features or phenotypes. Patients with severe asthma (SA) represent a group of asthmatics that are poorly responsive to medium-to-high doses of inhaled corticosteroids and additional controllers, thus leading in some cases to life-threatening disease exacerbations. To elaborate on SA heterogeneity, the concept of asthma endotypes has been developed, with the latter being characterized as T2-high or low, depending on the type of inflammation implicated in disease pathogenesis. As SA patients exhibit curtailed responses to standard-of-care treatment, biologic therapies are prescribed as adjunctive treatments. To date, several biologics that target specific downstream effector molecules involved in disease pathophysiology have displayed superior efficacy only in patients with T2-high, eosinophilic inflammation, suggesting that upstream mediators of the inflammatory cascade could constitute an attractive therapeutic approach for difficult-to-treat asthma. One such appealing therapeutic target is thymic stromal lymphopoietin (TSLP), an epithelial-der

Who reads Severe Asthmatic Responses: The Impact of TSLP?

Author

Efthymia Theofani; Aikaterini Tsitsopoulou; Ioannis Morianos; Maria Semitekolou

Publisher

MDPI AG

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)