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What is MALT-1 Inhibits Autophagy in C. elegans about?

The study investigates the role of MALT-1 in C. elegans, revealing that silencing MALT-1 expression in the intestine significantly extends lifespan by enhancing autophagy. Conversely, overexpression of MALT-1 shortens lifespan, indicating its function as an inhibitor of autophagy. The findings suggest that MALT-1 limits longevity by acting on early autophagy processes, particularly under starvation conditions.

Author

Nguyen Vinh

Language

EN