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Association of the PTPN22 R620W polymorphism with anti–topoisomerase I– and anticentromere antibody–positive systemic sclerosis by Pravitt Gourh; Filemon K. Tan; Shervin Assassi; Chul W. Ahn; Terry A. McNearney; Michael Fischbach; Frank C. Arnett; Maureen D. Mayes is a Medicine article available to read on EtoBox.
What is Association of the PTPN22 R620W polymorphism with anti–topoisomerase I– and anticentromere antibody–positive systemic sclerosis about?
## Abstract ## Objective To determine any associations of the __PTPN22__ R620W single‐nucleotide polymorphism (SNP) with systemic sclerosis (SSc) or with anticentromere antibody (ACA)–positive or anti–topoisomerase I (anti–topo I) antibody–positive SSc, in a case–control study of US white, black, Hispanic, and Choctaw Indian individuals. ## Methods A total of 850 white, 130 black, 120 Hispanic, and 20 Choctaw Indian patients with SSc were compared with 430 white, 164 black, 146 Hispanic, and 76 Choctaw Indian control subjects, respectively. All subjects were living in the US. __PTPN22__ SNP (rs2476601) genotyping was performed by TaqMan 5′ allelic discrimination assay and pyrosequencing. ## Results The __PTPN22__ CT/TT genotype showed significant association with anti–topo I antibody–positive SSc in white patients (odds ratio [OR] 2.21, 95% confidence interval [95% CI] 1.3–3.7) and with ACA‐positive white patients with SSc (OR 1.70, 95% CI 1.1–2.7). Frequency of the __PTPN22__\*T allele also showed significant association with anti–topo I antibody–positive SSc in white patients (OR 2.03, 95% CI 1.3–3.2). When data for patients in the 3 ethnic groups (black, white, and Hispanic) wer
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- Author
- Pravitt Gourh; Filemon K. Tan; Shervin Assassi; Chul W. Ahn; Terry A. McNearney; Michael Fischbach; Frank C. Arnett; Maureen D. Mayes
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)