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Cinobufacini suppresses malignant behaviors of endometrial cancer by regulating NF-κB pathway by Mengyi Sun; Xiaodao Han; Xiaoyun Liu; Yintao Xu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cinobufacini suppresses malignant behaviors of endometrial cancer by regulating NF-κB pathway about?

Cinobufagin has inhibitory effects on various tumors, but there are few studies on gynecological tumors. This study explored the function and molecular mechanism of cinobufagin in endometrial cancer (EC). Different concentrations of cinobufagin treated EC cells (Ishikawa and HEC-1). Clone formation, methyl thiazolyl tetrazolium (MTT), flow cytometry, and transwell assays were used to detect malignant behaviors. A Western blot assay was performed to detect protein expression. Cinobufacini was sensitive to the inhibition of EC cell proliferation in a time-and concentrationdependent manner. Meanwhile, EC cell apoptosis was induced by cinobufacini. In addition, cinobufacini impaired the invasive and migratory abilities of EC cells. More importantly, cinobufacini blocked the nuclear factor kappa beta (NF-κB) pathway in EC by inhibiting p-IkBα and p-p65 expression. Cinobufacini suppresses malignant behaviors of EC by blocking the NF-κB pathway.

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Author

Mengyi Sun; Xiaodao Han; Xiaoyun Liu; Yintao Xu

Publisher

Informa UK Limited

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)