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Neoadjuvant Chemotherapy With Capecitabine Plus Cisplatin in Patients With Locally Advanced Nasopharyngeal Cancer: Case Series Study by Dada, Reyad; El Sayed, Mohamed; Zekri, Jamal is a Medicine article available to read on EtoBox.

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## Purpose Capecitabine, an oral fluorouracil (5-FU) derivative, has replaced 5-FU in many chemotherapy regimens used in various GI tract cancers. The experience with capecitabine in nasopharyngeal carcinoma (NPC) is limited. ## Patients and Methods We report on eight patients with locally advanced NPC treated with neoadjuvant chemotherapy with capecitabine and cisplatin. ## Results All eight patients responded well to the chemotherapy combination and achieved complete remission after definitive chemoradiotherapy. No grade 3/4 toxicities were observed. Five patients experienced a relapse after 6, 8, 9, 12, and 17 months. ## Conclusion In the patients studied, capecitabine (in combination with cisplatin) was a safe and effective substitution for 5-FU for the neoadjuvant treatment of locally advanced NPC. Larger prospective clinical studies are required to confirm these results.

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Author

Dada, Reyad; El Sayed, Mohamed; Zekri, Jamal

Publisher

American Society of Clinical Oncology; Alexandria VA: American Society of Clinical Oncology, 2015-; American Society of Clinical Oncology (ASCO) (ISSN 2378-9506)

Published

2017

Language

EN

Field

Medicine (Health Sciences)