Opening book details…
Can I read Immunohistochemical Analysis of Progesterone Receptor and Ki-67 Labeling Index in Astrocytic Tumors on EtoBox?
Immunohistochemical Analysis of Progesterone Receptor and Ki-67 Labeling Index in Astrocytic Tumors by Humayun Khalid; Shobu Shibata; Masao Kishikawa; Akio Yasunaga; Masachika Iseki; Tsuyoshi Hiura is a Medicine article available to read on EtoBox.
What is Immunohistochemical Analysis of Progesterone Receptor and Ki-67 Labeling Index in Astrocytic Tumors about?
## Background: Intracranial tumors such as meningiomas express steroid hormone receptors but little is known regarding progesterone receptor (pr) in astrocytic tumors. the authors evaluated expression of pr in 86 astrocytic tumors in relation to tumor proliferative potential. ## Methods: Paraffin embedded tumor sections were stained with polyclonal antiprogesterone antibody by the peroxidase-antiperoxidase method and with monoclonal mib-1-ki-67 antibody by avidin-biotin complex immunohistochemistry. ## Results: Sixty-three of the 86 astrocytic tumors (73%) showed positive pr immunoreactivity. pr expression was observed in 4 of 9 pilocytic astrocytomas, 13 of 24 grade 2 astrocytomas, 15 of 20 anaplastic astrocytomas, and 31 of 33 glioblastomas. in addition to the tumor cells, cells of microvascular endothelial proliferation and the smooth muscle of tumor vessel walls were frequently pr positive. glioblastomas had a significantly higher percentage of pr positive cells compared with anaplastic (p < 0.0008) and low grade (p < 0.0001) astrocytomas. patients with pr positive astrocytomas were of an older age than patients with pr negative astrocytomas (48.71 +/- 21.95 years vs. 37.09 +/-
Who reads Immunohistochemical Analysis of Progesterone Receptor and Ki-67 Labeling Index in Astrocytic Tumors?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Humayun Khalid; Shobu Shibata; Masao Kishikawa; Akio Yasunaga; Masachika Iseki; Tsuyoshi Hiura
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)