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Neoadjuvant Antiangiogenic Therapy with Tamoxifen Does Not Impair Gastrointestinal Anastomotic Repair in the Rat by D. A. McNamara; T. N. Walsh; E. Kay; David J. Bouchier-Hayes is a Medicine article available to read on EtoBox.

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## Abstract **Introduction** Antiangiogenic therapy has the potential to moderate tumour and micrometastatic growth. Its use in the perioperative period is attractive but its potential to compromise wound and anastomotic healing is a cause for concern. Tamoxifen is antiangiogenic but also favourably modifies some aspects of wound healing. We hypothesised that tamoxifen would not adversely affect skin wound and gut anastomotic healing. **Methods** A previously established model of tamoxifen, administered orally at antiangiogenic doses (20 mg/ml arachais oil/day), was used. Animals received two days pretreatment prior to laparotomy and small bowel anastomosis. Treatment was continued until completion of the study. The principal outcome measures are survival, macroscopic wound and anastomotic healing, anastomotic bursting pressure and PVA sponge granuloma hydroxyproline (OHP) content. **Results** Tamoxifen treated animals had fewer complications of skin wound healing than controls (4.5%__vs.__ 19.5%; χ^2^ 4.65, 1 d.f., __P__ < 0.05). There was no significant difference in adhesion formation or macroscopic complications of anastomotic healing. Anastomotic bursting pressure was greater

Who reads Neoadjuvant Antiangiogenic Therapy with Tamoxifen Does Not Impair Gastrointestinal Anastomotic Repair in the Rat?

Author

D. A. McNamara; T. N. Walsh; E. Kay; David J. Bouchier-Hayes

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1462-8910)

Published

2003

Language

EN

Field

Medicine (Health Sciences)