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Age‐related loss of extrastriatal dopamine D~2~‐like receptors in women by Valtteri Kaasinen; Nina Kemppainen; Kjell Någren; Hans Helenius; Timo Kurki; Juha O. Rinne is a Neuroscience article available to read on EtoBox.

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## Abstract Positron emission tomography (PET) studies have indicated that the __in vivo__ availability of dopamine D~2~‐like receptors declines with age in the human brain. Most of the studies have been carried out with healthy male subjects, or with subject groups containing both sexes. The authors have recently demonstrated that the availability of D~2~‐like receptors in the frontal cortex is higher in women than in men. The present study was aimed to further examine this phenomenon. Thirty‐seven healthy women (age range 22–78 years) were examined with PET and [^11^C]FLB 457, a high‐affinity tracer for the extrastriatal D~2~‐like receptors. A negative relationship between age and dopamine D~2~‐like receptor availability was seen in the frontal cortex (decrease of 12% per decade of life), the temporal cortex (9%) and the thalamus (6%). A non‐linear s‐shape association explained the relationship only in the frontal cortex, while in other regions the association was linear. Neither oestradiol nor progesterone levels had a significant relationship with the [^11^C]FLB 457 uptake in any of the brain regions studied after the effect of age was partialled out. The results indicate that:

Who reads Age‐related loss of extrastriatal dopamine D~2~‐like receptors in women?

Author

Valtteri Kaasinen; Nina Kemppainen; Kjell Någren; Hans Helenius; Timo Kurki; Juha O. Rinne

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)