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Efficacy and safety of postoperative bio-chemoradiotherapy using cetuximab and docetaxel for high-risk head and neck cancer patients in Japan by Goshi Nishimura; Osamu Shiono; Daisuke Sano; Kenichiro Yabuki; Yasuhiro Arai; Yoshihiro Chiba; Teruhiko Tanabe; Nobuhiko Oridate is a Medicine article available to read on EtoBox.
What is Efficacy and safety of postoperative bio-chemoradiotherapy using cetuximab and docetaxel for high-risk head and neck cancer patients in Japan about?
## Purpose: To confirm the efficacy and safety of cetuximab and docetaxel in postoperative radiotherapy for high-risk head and neck cancer patients who cannot to be administered high-dose cisplatin. ## Patients and methods: The eligibility criteria required stage iii-ivb head and neck cancer patients who had undergone total resection, and for whom pathological evaluation revealed positive or close margins in the primary site and/or extracapsular nodal extension and/or two or more nodal metastases. in each case, the patients general condition prevented the use of high-dose cisplatin. instead, they received cetuximab and docetaxel every week during a 66.6 gy course of postoperative radiotherapy. ## Results: Eleven patients were enrolled; the median follow-up period was 22 months, and the 1- and 2-year disease free survival rates were 91 and 55%, respectively. grade 3 adverse events included oral mucositis, radiation dermatitis, reduced white blood cell and neutrophil counts, lung infection, aspiration, and hyponatremia; however, no grade 4 adverse events were observed. ## Conclusion: Administration of cetuximab and docetaxel during postoperative radiotherapy for high-risk poor condit
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- Author
- Goshi Nishimura; Osamu Shiono; Daisuke Sano; Kenichiro Yabuki; Yasuhiro Arai; Yoshihiro Chiba; Teruhiko Tanabe; Nobuhiko Oridate
- Publisher
- Springer Science and Business Media LLC
- Published
- 2017
- Language
- EN
- Field
- Medicine (Health Sciences)