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A Light-activated Method for Repair of Corneal Surface Defects by Ying Wang; Irene E. Kochevar; Robert W. Redmond; Min Yao is a Medicine article available to read on EtoBox.

What is A Light-activated Method for Repair of Corneal Surface Defects about?

## Abstract ## Background and Objective Amniotic membrane transplantation (AMT) sealed with sutures has been routinely used to treat ocular surface defects (OSD). However, the sutures used to secure the graft on the cornea cause additional injury, infection, and scarring. A new light‐activated technique, called photochemical tissue bonding (PTB), has been developed for securing amniotic membrane (AM) over the corneal surface. The purpose of this study was to compare PTB versus traditional sutures in AMT for repair of OSD. ## Materials and Methods An OSD was created in the left eye of 40 rabbits. The eyes were randomized into two repair groups: AMT using sutures and AMT using PTB with 0.1% Rose Bengal (RB) and 532 nm laser at 0.4 W/cm^2^ for 200 seconds. Eyes were examined for re‐epithelialization, inflammation, neovascularization, and scarring histologically and biochemically on postoperative days 1, 3, 14, and 28. ## Results PTB strongly bonded AM over corneal defects. Corneal re‐epithelialization did not differ significantly between the suture and PTB groups. Histology, immunohistology and Western blotting revealed that the numbers of inflammatory cells and the level of tumor nec

Who reads A Light-activated Method for Repair of Corneal Surface Defects?

Author

Ying Wang; Irene E. Kochevar; Robert W. Redmond; Min Yao

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0196-8092)

Published

2011

Language

EN

Field

Medicine (Health Sciences)