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Tumor Ploidy as a Major Prognostic Factor in Advanced Ovarian Cancer by Cees J. Rodenburg; Cees J. Cornelisse; Peter A. M. Heintz; Jo Hermans; Gert Jan Fleuren is a Medicine article available to read on EtoBox.

What is Tumor Ploidy as a Major Prognostic Factor in Advanced Ovarian Cancer about?

Tumor ploidy was determined by flowcytometry (FCM) in paraffin-embedded tissue of 74 patients with advanced ovarian cancer (International Federation of Gynecology and Obstetrics [FIG01 2B, 3,4). Significant differences in survival and progression-free survival were found between classes of tumor ploidy as well as for several clinical parameters, including FIGO stage, histologic grade, diameter of the largest metastases, presence of ascites, peritoneal carcinomatosis, and size of residual tumor. In a Cox regression analysis, tumor ploidy and presence or absence of ascites were the only significant factors for survival, whereas ascites and residual tumor proved to be the significant parameters for progression-free survival. Tumor ploidy was strongly associated with tumor bulk, size of residual tumor, and histologic grade. Tumor ploidy was the same within different tumor sites in the majority of the cases. On the basis of these findings tumor ploidy is considered to be a major prognostic factor for survival in advanced ovarian cancer. Cancer 59:317-323, 1987. ITH MODERN TREATMENT consisting Of debulking W surgery followed by chemotherapeutic regimens including cisplatin, a complete re

Who reads Tumor Ploidy as a Major Prognostic Factor in Advanced Ovarian Cancer?

Author

Cees J. Rodenburg; Cees J. Cornelisse; Peter A. M. Heintz; Jo Hermans; Gert Jan Fleuren

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1987

Language

EN

ISBN

9782820590220

Field

Medicine (Health Sciences)