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Protein-conjugated Acrolein as a Biochemical Marker of Brain Infarction by Kazuei Igarashi; Keiko Kashiwagi is a Medicine article available to read on EtoBox.

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## Abstract The relationship between acrolein (CH~2~=CH‐CHO) and brain infarction is the focus of this review. It has been found that acrolein is produced mainly within cells from polyamines by polyamine oxidases (PAOs), especially from spermine by spermine oxidase during cell damage, and that acrolein is more toxic than reactive oxygen species (ROS) in a cell culture system. Thus, the possibility that acrolein and PAOs are good biochemical markers of stroke was tested because there are no other reliable biochemical markers at the early stage of stroke. Levels of protein‐conjugated acrolein (PC‐Acro) and PAOs (acrolein‐producing enzymes) were significantly increased in the plasma of stroke patients. The multiplied value of PC‐Acro by PAOs was nearly parallel with the size of stroke. Furthermore, when the combined measurements of PC‐Acro, interleukin‐6 (IL‐6) and C‐reactive protein (CRP) were evaluated along with age using a receiver operating characteristic (ROC) curve, even silent brain infarction (SBI), which is a small brain infarction, was indicated with approximately 84% sensitivity and specificity. These findings clearly indicate that acrolein is strongly correlated with cell

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Author

Kazuei Igarashi; Keiko Kashiwagi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1613-4125)

Published

2011

Language

EN

Field

Medicine (Health Sciences)