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Can I read Virulence among different types of hypervirulent Klebsiella pneumoniae with multi-locus sequence type (MLST)-11, Serotype K1 or K2 strains on EtoBox?
Virulence among different types of hypervirulent Klebsiella pneumoniae with multi-locus sequence type (MLST)-11, Serotype K1 or K2 strains by Wang, Tsui-Chin (author);Lin, Jung-Chung (author);Chang, Jen-Chang (author);Hiaso, Ya-Wen (author);Wang, Ching-Hsun (author);Chiu, Sheng‐Kung (author);Fung, Chang-Phone (author);Chang, Feng-Yee (author);Siu, L. Kristopher (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Virulence among different types of hypervirulent Klebsiella pneumoniae with multi-locus sequence type (MLST)-11, Serotype K1 or K2 strains about?
## Background Two different types of hypervirulent __K. pneumoniae__ (HvKp), the MLST-11 and serotype K1/K2 strains, have been frequently described in recent studies. Although these two types of strains were described to be HvKp, their virulence was not compared. In this study, in vitro and in vivo approaches were used to assess differences in virulence. ## Materials and methods A total of twenty-nine isolates, including 6 strains of each of serotype K1 and K2 isolates and 17 strains of ST11 isolates, were selected for this study. Phenotypic tests of virulence were performed by the string test and analysis of the virulent associated genes was detected by PCR. In vitro models of serum resistance and phagocytosis were used as the parameters to assess the virulence. In-frame deletion of virulence-associated genes was performed to study their contributions to virulence. The median lethal dose, i.e., the LD~50~, in mice was determined following IP injection. ## Results Although serotype K1 and K2 strains and ST11 isolates had similar virulence gene profiles, the ST11 isolates showed less serum and phagocytic resistance than the serotype K1/K2 isolates. The mouse lethality test revealed
Who reads Virulence among different types of hypervirulent Klebsiella pneumoniae with multi-locus sequence type (MLST)-11, Serotype K1 or K2 strains?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Wang, Tsui-Chin (author);Lin, Jung-Chung (author);Chang, Jen-Chang (author);Hiaso, Ya-Wen (author);Wang, Ching-Hsun (author);Chiu, Sheng‐Kung (author);Fung, Chang-Phone (author);Chang, Feng-Yee (author);Siu, L. Kristopher (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)