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Correlation Analysis of Microribonucleic Acid‐155 and Microribonucleic Acid‐29 with Type 2 Diabetes Mellitus, and the Prediction and Verification of Target Genes by Jiaojiao Zhu; Cuizhe Wang; Xueting Zhang; Tongtong Qiu; Yinghua Ma; Xue Li; Huai Pang; Jianyu Xiong; Xin Yang; Chongge Pan; Jianxin Xie; Jun Zhang is a Medicine article available to read on EtoBox.
What is Correlation Analysis of Microribonucleic Acid‐155 and Microribonucleic Acid‐29 with Type 2 Diabetes Mellitus, and the Prediction and Verification of Target Genes about?
## Abstract ## Aims/Introduction Microribonucleic acid‐155 (microRNA155) and microRNA29 are reported to inhibit glucose metabolism in some cell and animal models, but no evidence from susceptible populations that examines the relationship between microRNA155 or microRNA29 and type 2 diabetes mellitus currently exists. Furthermore, target genes regulated by microRNA155 and microRNA29 that affect glucose and lipid metabolism remain unknown. ## Materials and Methods Human participants were divided into normal weight (__n__ = 72), obesity (__n__ = 120) and type 2 diabetes (__n__ = 59) groups. The contents of microRNA155 and microRNA29 abundance in serum were measured, and candidate genes potentially related to glucose and lipid metabolism targeted by either microRNA155 or microRNA29 were screened. Overexpression of microRNA155 and microRNA29 in HepG2 cells was used to verify candidate gene expression, and measure the effects on glucose and lipid metabolism. ## Results Serum levels of microRNA155 and microRNA29 show a significant increase in individuals with obesity and type 2 diabetes compared with normal weight individuals. Identified target genes for microRNA155 were __MAPK14__, __MA
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- Author
- Jiaojiao Zhu; Cuizhe Wang; Xueting Zhang; Tongtong Qiu; Yinghua Ma; Xue Li; Huai Pang; Jianyu Xiong; Xin Yang; Chongge Pan; Jianxin Xie; Jun Zhang
- Publisher
- Wiley
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)