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Association Between Earwax‐Determinant Genotypes and Acquired Middle Ear Cholesteatoma in a Japanese Population by Satoshi Hara; Takeshi Kusunoki; Hiroshi Nakagawa; Yu Toyoda; Shuko Nojiri; Kazusaku Kamiya; Masayuki Furukawa; Yusuke Takata; Hiroko Okada; Takashi Anzai; Fumihiko Matsumoto; Katsuhisa Ikeda is a Medicine article available to read on EtoBox.
What is Association Between Earwax‐Determinant Genotypes and Acquired Middle Ear Cholesteatoma in a Japanese Population about?
## Objective A single‐nucleotide polymorphism 538G>A in the human ABCC11 gene is a determinant of the earwax morphotype. ABCC11 538GG and GA correspond to wet earwax and 538AA to dry earwax. Despite a putative positive correlation between the frequency of the 538G allele and the prevalence of cholesteatoma, minimal clinical information is currently available. We aimed to evaluate this association between the ABCC11 genotypes and acquired middle ear cholesteatoma. ## Study Design Case‐control study. ## Setting Single‐center academic hospital. ## Methods We recruited 67 Japanese patients with acquired middle ear cholesteatoma (cholesteatoma group) and 100 Japanese controls with no history of middle ear cholesteatoma. We assessed the ABCC11 genotypes for all participants. Clinical information was collected from the cholesteatoma group. The genotype data of 104 Japanese people from the 1000 Genomes Project who represent the general population were used. ## Results The proportion of participants with ABCC11 538GG or GA was significantly higher in the cholesteatoma group than in the control group or general Japanese population (P <. 001). The ABCC11 538G allele frequency was also signifi
Who reads Association Between Earwax‐Determinant Genotypes and Acquired Middle Ear Cholesteatoma in a Japanese Population?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Satoshi Hara; Takeshi Kusunoki; Hiroshi Nakagawa; Yu Toyoda; Shuko Nojiri; Kazusaku Kamiya; Masayuki Furukawa; Yusuke Takata; Hiroko Okada; Takashi Anzai; Fumihiko Matsumoto; Katsuhisa Ikeda
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)