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What is Clozapine Enhances LTP via D1 Receptors about?

This study investigates the effects of clozapine on synaptic plasticity, specifically long-term potentiation (LTP), in the hippocampal–medial prefrontal cortex (mPFC) pathway of anesthetized rats. The results indicate that clozapine enhances LTP through dopamine D1 receptor activation, while typical antipsychotic haloperidol does not have the same effect. These findings suggest that the therapeutic effects of clozapine in cognitive dysfunction may be linked to its ability to augment synaptic plasticity via

Author

ceecheve

Language

EN