Can I read Lewy Body Dementia Promotion by Air Pollutants on EtoBox?

Lewy Body Dementia Promotion by Air Pollutants by Xiaodi Zhang†, Haiqing Liu†, Xiao Wu†, Longgang Jia†, is a nonfiction available to read on EtoBox.

What is Lewy Body Dementia Promotion by Air Pollutants about?

INTRODUCTION: Lewy body dementia (LBD), comprising dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) with dementia (PDD), is a devastating and increasingly prevalent neurodegenerative disorder. Ambient PM2.5 is a recognized broad dementia risk factor; however, its specific role in initiating LBD, particularly its distinct pathological trajectory versus PD without dementia, remains unaddressed. This study systematically investigates this link. RATIONALE: Pathologic α-synuclein (αSyn) is the defining neuropathological hallmark of LBD. A leading hypothesis posits that environmental neurotoxins, such as fine particulate matter (PM2.5), could trigger initial αSyn misfolding and propagation into the brain. However, epidemiological relationships between PM2.5 exposure and LBD versus PD subtypes lacked large-scale substantiation. Whether PM2.5 can induce αSyn to form pathogenic strains that drive LBD’s specific clinical and pathological signatures remains unclear. Elucidating this environmental-molecular nexus is key to unravelling LBD pathogenesis and identifying targeted interventions. Our study aimed to dissect these fundamental mechanisms.RESULTS: Convergent, multimodal ev

Who reads Lewy Body Dementia Promotion by Air Pollutants?

Author

Xiaodi Zhang†, Haiqing Liu†, Xiao Wu†, Longgang Jia†,

Published

2025

Language

EN

Category

nonfiction

Subjects

Medical, Epidemiology, Medicine