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Can I read MicroRNA‐493‐5p‐mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion on EtoBox?
MicroRNA‐493‐5p‐mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion by Ken Yasukawa; Lee Chuen Liew; Keitaro Hagiwara; Ai Hironaka‐Mitsuhashi; Xian‐Yang Qin; Yutaka Furutani; Yasuhito Tanaka; Hitoshi Nakagama; Soichi Kojima; Takashi Kato; Takahiro Ochiya; Luc Gailhouste is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is MicroRNA‐493‐5p‐mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion about?
## Abstract Primary hepatic tumors mainly include hepatocellular carcinoma (HCC), which is one of the most frequent causes of cancer‐related deaths worldwide. Thus far, HCC prognosis has remained extremely poor given the lack of effective treatments. Numerous studies have described the roles played by microRNAs (miRNAs) in cancer progression and the potential of these small noncoding RNAs for diagnostic or therapeutic applications. The current consensus supports the idea that direct repression of a wide range of oncogenes by a single key miRNA could critically affect the malignant properties of cancer cells in a synergistic manner. In this study, we aimed to investigate the oncogenes controlled by miR‐493‐5p, a major tumor suppressor miRNA that inactivates miR‐483‐3p oncomir in hepatic cancer cells. Using global gene expression analysis, we highlighted a set of candidate genes potentially regulated by miR‐493‐5p. In particular, the canonical MYCN protooncogene (__MYCN__) appeared to be an attractive target of miR‐493‐5p given its significant inhibition through 3′‐UTR targeting in miR‐493‐5p‐rescued HCC cells. We showed that __MYCN__ was overexpressed in liver cancer cell lines and
Who reads MicroRNA‐493‐5p‐mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ken Yasukawa; Lee Chuen Liew; Keitaro Hagiwara; Ai Hironaka‐Mitsuhashi; Xian‐Yang Qin; Yutaka Furutani; Yasuhito Tanaka; Hitoshi Nakagama; Soichi Kojima; Takashi Kato; Takahiro Ochiya; Luc Gailhouste
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Research Square (ISSN 1347-9032)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)