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LL‐37 fragments have antimicrobial activity against Staphylococcus epidermidis biofilms and wound healing potential in HaCaT cell line by Paola Saporito; Michelle Vang Mouritzen; Anders Løbner‐Olesen; Håvard Jenssen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is LL‐37 fragments have antimicrobial activity against Staphylococcus epidermidis biofilms and wound healing potential in HaCaT cell line about?

__Staphylococcus epidermidis__ is a common nosocomial pathogen able to form biofilms in indwelling devices, resulting in chronic infections, which are refractory to antibiotics treatment. Staphylococcal biofilms are also associated with the delayed reepithelization and healing of chronic wounds. The human cathelicidin peptide LL‐37 has been proven active against __S. epidermidis__ biofilms in vitro and to promote wound healing. As previous studies have demonstrated that fragments of LL‐37 could possess an equal antibacterial activity as the parent peptide, we tested whether shorter (12‐mer) synthetic fragments of LL‐37 maintained the antibiofilm and/or immune modulating activity, aiming at the identification of essential regions within the LL‐37 parent sequence. Three fragments of LL‐37 displayed improved activity against __S. epidermidis__ in terms of biofilm inhibition and eradication, a reduced cytotoxicity to human keratinocytes and erythrocytes. In addition, KR‐12 and VQ‐12^V26^ enhanced wound healing potential, relative to LL37. FK‐12 and KR‐12 are truncated version of the cathelicidin, previously reported as valid antimicrobials, whereas VQ‐12^V26^ is a single substituted LL

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Author

Paola Saporito; Michelle Vang Mouritzen; Anders Løbner‐Olesen; Håvard Jenssen

Publisher

Wiley

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)