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Structure and Function of “Metalloantibiotics” by Li‐June Ming is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Although most antibiotics do not need metal ions for their biological activities, there are a number of antibiotics that require metal ions to function properly, such as bleomycin (BLM), streptonigrin (SN), and bacitracin. The coordinated metal ions in these antibiotics play an important role in maintaining proper structure and/or function of these antibiotics. Removal of the metal ions from these antibiotics can cause changes in structure and/or function of these antibiotics. Similar to the case of “metalloproteins,” these antibiotics are dubbed “metalloantibiotics” which are the title subjects of this review. Metalloantibiotics can interact with several different kinds of biomolecules, including DNA, RNA, proteins, receptors, and lipids, rendering their unique and specific bioactivities. In addition to the microbial‐originated metalloantibiotics, many metalloantibiotic derivatives and metal complexes of synthetic ligands also show antibacterial, antiviral, and anti‐neoplastic activities which are also briefly discussed to provide a broad sense of the term “metalloantibiotics.” © 2003 Wiley Periodicals, Inc. Med Res Rev, 23 No. 6, 697–762, 2003

Who reads Structure and Function of “Metalloantibiotics”?

Author

Li‐June Ming

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0198-6325)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)