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Solvent-dependent Properties of Electrospun Fibrous Composites for Bone Tissue Regeneration by A. Patlolla; G. Collins; T. Livingston Arinzeh is a Engineering article available to read on EtoBox.

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Biodegradable polymer-ceramic composite scaffolds have gained importance in recent years in the field of orthopedic biomaterials and tissue engineering scaffolds for improving the rate of degradation and limited mechanical properties of bioactive ceramics. This study sought to create composites using the electrospinning process to achieve fibrous scaffolds with uniform fiber morphologies and uniform ceramic dispersions. Composites consisting of 20% hydroxyapatite/80% b-tricalcium phosphate (20/80 HA/ TCP) and poly (e-caprolactone) (PCL) were fabricated. The 20/80 HA/TCP composition was chosen as the ceramic component because of previous reports of greater bone tissue formation in comparison with HA or TCP alone. For electrospinning, PCL was dissolved in either methylene chloride (Composite-MC) or a combination of methylene chloride (80%) and dimethylformamide (20%) (Composite-MC + DMF). Composite-MC mats contained a bimodal distribution of fiber diameters with nanofibers between larger, micron-sized fibers with an average pore size of 79.6 ± 67 lm, whereas Composite-MC + DMF fibers had uniform fiber diameters with an average pore size of 7.0 ± 4.2 lm. Elemental mapping determined t

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Author

A. Patlolla; G. Collins; T. Livingston Arinzeh

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1742-7061)

Published

2010

Language

EN

Field

Engineering (Physical Sciences)