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Expression patterns of the Wtx/Amer gene family during mouse embryonic development by Glenda Comai; Agnes Boutet; Yasmine Neirijnck; Andreas Schedl is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract WTX/AMER1 is a novel negative regulator of the WNT/β‐catenin pathway with mutations detected in Wilms' tumors and an X‐linked sclerosing bone dysplasia. WTX/AMER1 (__Fam123b__) shares several domains of homology with two other recently identified proteins: AMER2 (__Fam123a__) and AMER3 (__Fam123c__). Here, we describe an in‐depth expression analysis of all three members of this gene family during mouse embryonic development. All genes were strongly expressed in the central as well as the peripheral nervous system, thus suggesting important roles of this gene family during neurogenesis. Specific expression was found in the retina, inner ear, and nasal epithelium. Outside of the nervous system __Wtx/Amer1__ showed the broadest expression domains including cephalic and limb mesenchyme, skeletal muscle, bladder, gonads, lung bud, salivary glands, and the kidneys. The widespread expression pattern of __Wtx/Amer1__, together with its role as a modulator of the Wnt signaling pathway, suggest that __Wtx/Amer1__ serves pleiotropic roles during mammalian organogenesis. Developmental Dynamics 239:1867–1878, 2010. © 2010 Wiley‐Liss, Inc.

Who reads Expression patterns of the Wtx/Amer gene family during mouse embryonic development?

Author

Glenda Comai; Agnes Boutet; Yasmine Neirijnck; Andreas Schedl

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1058-8388)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)