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Involvement of Different Risk Factors in Clinically Severe Large Joint Osteoarthritis According to the Presence of Hand Interphalangeal Nodes by Ana M. Valdes; Daniel McWilliams; Nigel K. Arden; Sally A. Doherty; Margaret Wheeler; Kenneth R. Muir; Weiya Zhang; Cyrus Cooper; Rose A. Maciewicz; Michael Doherty is a Medicine article available to read on EtoBox.
What is Involvement of Different Risk Factors in Clinically Severe Large Joint Osteoarthritis According to the Presence of Hand Interphalangeal Nodes about?
## Abstract ## Objective To quantify the differences in risk factors influencing total hip replacement (THR) and total knee replacement (TKR) based on the presence versus absence of multiple interphalangeal nodes in 2 or more rays of the fingers of each hand in patients with large joint osteoarthritis (OA). ## Methods A group of 3,800 patients with large joint OA who underwent total joint replacement (1,201 of whom had the nodal phenotype) and 1,906 control subjects from 2 case–control studies and a population‐based cohort in the UK were studied. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for the risk of total joint replacement in association with age, sex, body mass index (BMI), height, and prevalence of the T allele in the __GDF5__ rs143383 polymorphism. ORs for total joint replacement were compared between cases of nodal OA and cases of non‐nodal OA and between patients who underwent TKR and those who underwent THR. ## Results Age, sex, and BMI had significantly higher ORs for an association with total joint replacement in nodal OA cases than in non‐nodal OA cases. The __GDF5__ polymorphism was significantly associated with THR in cases of nodal OA,
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- Author
- Ana M. Valdes; Daniel McWilliams; Nigel K. Arden; Sally A. Doherty; Margaret Wheeler; Kenneth R. Muir; Weiya Zhang; Cyrus Cooper; Rose A. Maciewicz; Michael Doherty
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)