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Can I read Role of the Tumour Microenvironment in Bladder Cancer Pathogenesis and Value of the Reverse Translational Approach: a Tale of Two Species on EtoBox?
Role of the Tumour Microenvironment in Bladder Cancer Pathogenesis and Value of the Reverse Translational Approach: a Tale of Two Species by Basant H. Ahmed; Christopher Zdyrski; John Cheville; Nicholas Rancilio; Alex M. Abel; Wesley A. Wierson; Jodi L. McGill; Jonathan P. Mochel; Karin Allenspach is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Role of the Tumour Microenvironment in Bladder Cancer Pathogenesis and Value of the Reverse Translational Approach: a Tale of Two Species about?
## Abstract ## Background Bladder cancer is a significant malignancy in humans and canines, with high death rates and devastating clinical symptoms. Despite significant advances in therapeutic management over the years, only a small fraction of bladder cancer patients respond to immunotherapies as a second line of treatment. Since immunotherapies act on various cellular and molecular targets in the bladder cancer tumour microenvironment (TME), a greater understanding of the various types of immune cells, immune checkpoint molecules and cytokines involved in antitumour immunity will help to improve the success rate of current and novel immunotherapies, therefore enhancing the patients quality of life. Accumulating evidence shows fundamental similarities between human and canine muscle‐invasive bladder cancer (MIBC) in their clinical, histological and molecular features. ## Aim This review focuses on comparative aspects of MIBC in both species, highlighting the role that canines can play as a model for studying MIBC. Additionally, we discuss the various types of immune cells within bladder cancer TME that can influence the prognosis and response to immunotherapy and chemotherapy in b
Who reads Role of the Tumour Microenvironment in Bladder Cancer Pathogenesis and Value of the Reverse Translational Approach: a Tale of Two Species?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Basant H. Ahmed; Christopher Zdyrski; John Cheville; Nicholas Rancilio; Alex M. Abel; Wesley A. Wierson; Jodi L. McGill; Jonathan P. Mochel; Karin Allenspach
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)