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N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice by Dai-fei Shen; He Cheng; Bo-zhi Cai; Wen-feng Cai; Bin Wang; Qing Zhu; Yue-bin Wu; Man Liu; Run-ji Chen; Fen-fei Gao; Yan-mei Zhang; Yong-dong Niu; Gang-gang Shi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice about?
N-n-Butyl haloperidol iodide (F) is a novel compound that has antiproliferative and antifibrogenic activities. In this study we investigated the therapeutic potential of F against liver fibrosis in mice and the underlying mechanisms. Two widely used mouse models of fibrosis was established in mice by injection of either carbon tetrachloride (CCl) or thioacetamide (TAA). The mice received F (0.75, 1.5 or 3 mg·kg·d, ip) for 4 weeks of fibrosis induction. We showed that F administration dose-dependently ameliorated CCl- or TAA-induced liver fibrosis, evidenced by significant decreases in collagen deposition and c-Jun, TGF-β receptor II (TGFBR2), α-smooth muscle actin (α-SMA), and collagen I expression in the liver. In transforming growth factor beta 1 (TGF-β1)-stimulated LX-2 cells (a human hepatic stellate cell line) and primary mouse hepatic stellate cells, treatment with F (0.1, 1, 10 μM) concentration-dependently inhibited the expression of α-SMA, and collagen I. In LX-2 cells, F inhibited TGF-β/Smad signaling through reducing the levels of TGFBR2; pretreatment with LY2109761 (TGF-β signaling inhibitor) or SP600125 (c-Jun signaling inhibitor) markedly inhibited TGF-β1-induced indu
Who reads N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dai-fei Shen; He Cheng; Bo-zhi Cai; Wen-feng Cai; Bin Wang; Qing Zhu; Yue-bin Wu; Man Liu; Run-ji Chen; Fen-fei Gao; Yan-mei Zhang; Yong-dong Niu; Gang-gang Shi
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)