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Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats by Naikui Liu; Shu Han; Pei-Hua Lu; Xiao-Ming Xu is a Neuroscience article available to read on EtoBox.

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## Abstract The posttraumatic inflammatory reaction contributes to progressive tissue damage after spinal cord injury (SCI). Annexins, a family of structurally related calcium‐ and phospholipid‐binding proteins, have potent anti‐inflammatory effects by inhibiting the activity of phospholipase A~2~ (PLA~2~), a key enzyme responsible for inflammation and cytotoxicity. We investigated spatiotemporal expression of annexins I, II, and V after a contusive SCI using the New York University impact device (a 10‐g rod, height 12.5 mm) in adult rats. Western blot analysis revealed that annexin I expression increased at 3 days after injury, peaked at 7 days (1.75‐fold above the baseline level; __P__ < 0.01), started to decline at 14 days, and returned to the baseline level at and beyond 28 days post‐injury. The expression of annexin II started to increase at 3 days, reached its maximal level at 14 days (2.73‐fold; __P__ < 0.01), remained at a high level up to 28 days, and then declined to the basal level by 56 days after injury. Annexin V expression started at 3 days, reached its maximal level at 7 days (1.61‐fold; __P__ < 0.05) and remained at this level until 56 days after injury. RT‐PCR res

Who reads Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats?

Author

Naikui Liu; Shu Han; Pei-Hua Lu; Xiao-Ming Xu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

2004

Language

EN

Field

Neuroscience (Life Sciences)