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This systematic review examines the evidence for newer generations of autologous chondrocyte implantation (ACI) compared to first-generation ACI. It identified 7 relevant studies that compared newer ACI techniques like collagen membrane-based ACI and scaffold-based ACI to earlier periosteum-based ACI. The review found weak evidence that collagen membrane-based ACI may be better than periosteum-based ACI and that scaffold-based ACI is comparable, but noted limitations like short follow-up periods, small pati

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limin

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EN