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DNA precursor asymmetries, replication fidelity, and variable genome evolution by Christopher K. Mathews; Jiuping Ji is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is DNA precursor asymmetries, replication fidelity, and variable genome evolution about?

## Abstract Balanced pools of deoxyribonucleoside triphosphates (dNTPs) are essential for DNA replication to occur with maximum fidelity. Conditions that create biased dNTP pools stimulate mutagenesis, as well as other phenomena, such as recombination or cell death. In this essay we consider the effective dNTP concentrations at replication sites under normal conditions, and we ask how maintenance of these levels contributes toward the natural fidelity of DNA replication. We focus upon two questions. (1) In prokaryotic systems, evidence suggests that replication is driven by small, localized, rapidly replenished dNTP pools that do not equilibrate with the bulk dNTP pools in the cell. Since these pools cannot be analyzed directly, what indirect approaches can illuminate the nature of these replication‐active pools? (2) In eukaryotic cells, the normal dNTP pools are highly asymmetric, with dGTP being the least abundant nucleotide. Moreover, the composition of the dNTP pools changes as cells progress through the cell cycle. To what extent might these natural asymmetries contribute toward a recently described phenomenon, the differential rate of evolution of different genes in the same

Who reads DNA precursor asymmetries, replication fidelity, and variable genome evolution?

Author

Christopher K. Mathews; Jiuping Ji

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0265-9247)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)