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Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder by Daniel J. Müller; Thomas G. Schulze; Esther Jahnes; Sven Cichon; Harald Krauss; Kristina Kesper; Tilo Held; Wolfgang Maier; Peter Propping; Markus M. Nöthen; Marcella Rietschel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder about?
## Abstract In the past decade, several chromosomal regions have been analyzed for linkage with bipolar affective disorder (BPAD). There have been conflicting results regarding the involvement of X‐chromosomal regions in harboring susceptibility genes for BPAD. Recently, a new candidate gene (__SYBL1__) for BPAD has been described on Xq28. __SYBL1__, which maps to the Xq pseudoautosomal region (PAR), encodes a member of the synaptobrevin family of proteins involved in synaptic vesicle docking, exocytosis, and membrane transport. A subsequent case‐control association study, including 110 US‐American patients with BPAD and 119 unrelated controls, investigated a potential etiological role of a novel polymorphism (G→C transversion) in a regulatory region of the __SYBL1__ gene. In this analysis, the C allele showed a statistical trend to be more frequent in males with BPAD than in respective controls (__P__ = 0.06). This finding prompted us to verify whether a similar effect was also present in a larger German sample of 164 unrelated patients with BPAD (148 patients with BP I disorder, 16 patients with BP II disorder) and 267 controls. We observed a significantly increased frequency of
Who reads Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Daniel J. Müller; Thomas G. Schulze; Esther Jahnes; Sven Cichon; Harald Krauss; Kristina Kesper; Tilo Held; Wolfgang Maier; Peter Propping; Markus M. Nöthen; Marcella Rietschel
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)