Can I read Signaling Pathways in Hepatocellular Carcinoma on EtoBox?

Signaling Pathways in Hepatocellular Carcinoma by Teresa Garcia-Lezana; Juan Luis Lopez-Canovas; Augusto Villanueva is a book available to read on EtoBox.

What is Signaling Pathways in Hepatocellular Carcinoma about?

Despite the recent introduction of new effective systemic agents, the survival of patients with hepatocellular carcinoma (HCC) at advanced stages remains dismal. This underscores the need for new therapies, which has spurred extensive research on the identification of the main drivers of pathway de-regulation as a source of novel therapeutic targets. Frequently altered pathways in HCC involve growth factor receptors (e.g., VEGFR, FGFR, TGFA, EGFR, IGFR) and/or its cytoplasmic intermediates (e.g., PI3K-AKT-mTOR, RAF/ERK/MAPK) as well as key pathways in cell differentiation (e.g., Wnt/β-catenin, JAK/STAT, Hippo, Hedgehog, Notch). Somatic mutations, chromosomal aberrations and epigenetic changes are common mechanisms for pathway deregulation in HCC. Aberrant pathway activation has also been explored as a biomarker to predict response to specific therapies, but currently, these strategies are not implemented when deciding systemic therapies in HCC patients. Beyond the well-established molecular cascades, there are numerous emerging signaling pathways also deregulated in HCC (e.g., tumor microenvironment, non-coding RNA, intestinal microbiota), which have opened new avenues for therapeu

Author

Teresa Garcia-Lezana; Juan Luis Lopez-Canovas; Augusto Villanueva

Publisher

Academic Press, an imprint of Elsevier

Published

2021

Language

EN

ISBN

9780128240304

Subjects

Science, Medical, Biology