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Subthalamic 85 Hz deep brain stimulation improves walking pace and stride length in Parkinson’s disease patients by F. Mügge; U. Kleinholdermann; A. Heun; M. Ollenschläger; J. Hannink; D. J. Pedrosa is a Medicine article available to read on EtoBox.

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## Background Mobile gait sensors represent a compelling tool to objectify the severity of symptoms in patients with idiopathic Parkinson’s disease (iPD), but also to determine the therapeutic benefit of interventions. In particular, parameters of Deep Brain stimulation (DBS) with its short latency could be accurately assessed using sensor data. This study aimed at gaining insight into gait changes due to different DBS parameters in patients with subthalamic nucleus (STN) DBS. ## Methods An analysis of various gait examinations was performed on 23 of the initially enrolled 27 iPD patients with chronic STN DBS. Stimulation settings were previously adjusted for either amplitude, frequency, or pulse width in a randomised order. A linear mixed effects model was used to analyse changes in gait speed, stride length, and maximum sensor lift. ## Results The findings of our study indicate significant improvements in gait speed, stride length, and leg lift measurable with mobile gait sensors under different DBS parameter variations. Notably, we observed positive results at 85 Hz, which proved to be more effective than often applied higher frequencies and that these improvements were traceabl

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Author

F. Mügge; U. Kleinholdermann; A. Heun; M. Ollenschläger; J. Hannink; D. J. Pedrosa

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Medicine (Health Sciences)