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Chemokine Receptor Expression Profiles in Nasopharyngeal Carcinoma and Their Association with Metastasis and Radiotherapy by D-L Ou; C-L Chen; S-B Lin; C-H Hsu; L-I Lin is a Medicine article available to read on EtoBox.

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## Abstract Nasopharyngeal carcinoma (NPC) is an epithelial cancer that metastasizes predictably to cervical lymph nodes or distant organs. To assess whether the chemokine receptors of NPC cells play important roles in metastasis and are associated with radiotherapy history, the significance of various chemokine receptors (CCR1–10, CXCR1–6, XCR1, and CX3CR1) in NPC cell lines (TW01, TW04, HONE1, BM1, and AS1) and 52 NPC tumour biopsies from 48 patients with NPC was evaluated by mRNA and cytometric analyses, chemotaxis and actin polymerization assays, and immunohistochemical staining. Quantitative real‐time reverse transcription‐polymerase chain reaction revealed substantial expression of __CCR7, CCR9, CXCR4__, and __CXCR6__ mRNA in all the NPC cell lines. Of these, however, only CCR7, CXCR4, and CXCR6 were functional in NPC cells. Negative immunoreactivity for CCR7, CXCR4, and CXCR6 was demonstrated in almost all nasopharyngeal (NP) specimens from patients with primary NPC (__n__ = 12) and in those with regional metastatic NPC (__n__ = 15). However, expression of two or three of these chemokine receptors was demonstrated in NP specimens from patients with liver metastasis. Strong p

Who reads Chemokine Receptor Expression Profiles in Nasopharyngeal Carcinoma and Their Association with Metastasis and Radiotherapy?

Author

D-L Ou; C-L Chen; S-B Lin; C-H Hsu; L-I Lin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2006

Language

EN

Field

Medicine (Health Sciences)